Largest by Revenue Nonprofits in South Carolina

Largest by Revenue nonprofit rankings for South Carolina. 100 organizations with $2.8B in combined revenue. Updated 2026 IRS 990 data.

100Organizations
$2.8BTotal Revenue
$6.9BTotal Assets
77/100Avg Score

Largest by Revenue Rankings for South Carolina (100)

#OrganizationCityRevenueAssetsScore
1 Mcleod Physician Associates Ii Florence $258.0M $73.9M 45/100
2 Waccamaw Community Hospital Georgetown $225.6M $273.9M
3 Roper Saint Francis Physicians Network Ladson $213.1M $94.4M
4 Georgetown Hospital System Georgetown $209.6M $614.4M 55/100
5 Securing Assets For Education Moncks Corner $183.2M $161.0M 75/100
6 Roper St Francis Hospital Berkeley Inc Summerville $152.1M $281.9M
7 Coastal Community Foundation Of South Carolina Inc N Charleston $103.4M $435.6M
8 Guthrie Risk Retention Group Charleston $80.9M $53.9M 75/100
9 Darla Moore And Richard Rainwater Foundation Lake City $78.0M $658.1M
10 Bluecross Blueshield Of South Carolina Foundation Columbia $70.9M $357.9M
11 Genesis Healthcare Inc Columbia $65.9M $146.1M 90/100
12 South Carolina Connections Academy Inc Columbia $60.4M $36.9M
13 Meeting Street Schools Charleston $47.0M $307.7M 85/100
14 Charleston Educational Excellence Financing Corporation Charleston $45.0M $373.8M
15 College Of Charleston Foundation Charleston $40.4M $222.6M
16 Insurance Institute For Business & Home Safety Richburg $39.9M $55.9M
17 St Francis Physician Services Inc Greenville $36.9M $123.7M 60/100
18 Charleston Area Convention & Visitors Bureau Charleston $32.7M $23.2M
19 South Carolina Youth Advocate Program Inc Columbia $31.3M $64.3M
20 Sherman College Of Straight Chiropractic Inc Spartanburg $30.6M $43.3M
21 United States Endowment Forforestry And Communities Inc Greenville $28.6M $292.5M 85/100
22 Charleston School Of Law Charleston $27.1M $41.4M 60/100
23 Darnall W Boyd Foundation Inc Columbia $26.2M $148.7M
24 South Carolina Virtual Charter School West Columbia $26.0M $35.0M
25 Legacy Early College Greenville $25.5M $18.8M 85/100
26 University Of South Carolina Business Partnership Foundation Columbia $24.5M $173.2M
27 York Preparatory Academy Inc Rock Hill $22.6M $38.5M
28 Scago Educational Facilities Corporation For Pickens School Dis Easley $22.0M $163.3M 75/100
29 Rural Health Services Inc Aiken $21.5M $23.5M
30 Orange Grove Elementary Charter School Charleston $20.1M $24.0M 92/100
31 Francis Marion University Education Foundation Florence $16.6M $57.9M
32 Michael J Mungo Foundation Inc Irmo $16.0M $34.4M 92/100
33 Riverbanks Society Columbia $13.9M $17.0M
34 American Leprosy Missions Inc Greenville $13.8M $16.2M 90/100
35 Growth Summerville $13.6M $91.7M 65/100
36 Winthrop University Foundation Rock Hill $12.5M $92.6M
37 Canal Charitable Foundation Greenville $12.4M $249K 40/100
38 Riverview Charter School Inc Beaufort $12.1M $19.2M
39 Foothills Community Health Care Anderson $11.8M $12.6M
40 Chester Healthcare Foundation Chester $11.5M $17.6M
41 Secession Golf Club Inc Beaufort $11.3M $24.9M
42 International African American Museum Charleston $11.2M $73.5M 90/100
43 Hilton Head Preparatory School Hilton Head $10.4M $19.9M
44 East Point Academy West Columbia $10.4M $29.6M
45 Naturaland Trust Greenville $10.0M $58.2M
46 Midlands Technical College Foundation Inc Columbia $9.9M $21.4M
47 Center Of Excellence For Educator Preparation And Innovation Inc Denmark $9.7M $5.3M
48 South Carolina State University Foundation Inc Orangeburg $9.6M $22.7M
49 Fox Creek High School Inc North Augusta $9.4M $23.0M 92/100
50 Greenwood County Community Foundation Inc Greenwood $9.1M $26.7M
51 Kershaw County Public Schools Foundation Camden $9.0M $65.9M
52 Charleston Parks Conservancy Charleston $9.0M $9.2M 85/100
53 Oneworld Health Charleston $9.0M $7.5M
54 South Carolina Bar Foundation Inc Columbia $9.0M $34.1M
55 Columbia Empowerment Zone Inc Columbia $8.6M $12.9M
56 Institute For Child Success Inc Greenville $8.5M $5.6M
57 Southeastern Wildlife Exposition Inc Charleston $7.8M $6.1M
58 Francis Marion University Development Foundation Florence $7.8M $27.1M 88/100
59 Greer Middle College Charter High School Taylors $7.2M $16.3M 85/100
60 Spartanburg Preparatory School Spartanburg $7.2M $12.4M 75/100
61 East Cooper Montessori Charter School Mt Pleasant $7.2M $9.7M
62 South Carolina Community Loan Fund Charleston $6.9M $49.6M 90/100
63 Community Works Greenville $6.8M $36.5M
64 Campbell Young Leaders Greenville $6.8M $37.8M
65 Scago Educational Facilities Corporation For Colleton School Di Walterboro $6.7M $39.7M 65/100
66 Southeast Coastal Ocean Observing Regional Association Charleston $6.6M $2.6M
67 Cultural And Heritage Commission Of York County York $6.5M $7.6M
68 Orangeburg High School For Health Professions Orangeburg $6.4M $9.3M
69 Gba Ships Florence Inc Florence $6.4M $3.5M
70 Investsc Inc Columbia $6.3M $30.4M 65/100
71 Companion Foundation Charleston $6.3M $20.9M 65/100
72 Brashier Middle College Charter High School Inc Simpsonville $6.2M $5.8M 92/100
73 Southeastern Housing And Community Development Barnwell $6.1M $14.3M
74 Lexington One School Facilities Corporation Lexington $6.1M $73.0M 92/100
75 Zvejnieks Foundation Of South Carolina Elgin $5.9M $3.2M
76 Brown Family Foundation Gaffney $5.7M $9.8M
77 Lead Academy Greenville $5.7M $16.8M
78 Thornwell Charter School Clinton $5.6M $2.9M 90/100
79 Newberry Investing In Childrens Education Newberry $5.5M $36.4M 75/100
80 Fort Mill School Facilitiescorporation Fort Mill $5.4M $33.2M 90/100
81 Bmw Car Club Of America Inc Greer $5.4M $4.2M 85/100
82 Odyssey Online Learning Chapin $5.3M $6.2M
83 Palmetto Scholars Academy Inc N Charleston $5.3M $8.9M
84 Coydog Foundation Charleston $5.2M $39.9M
85 Look Up Lodge Christian Camp Inc Travelers Rst $5.2M $12.3M 90/100
86 Midlands Housing Alliance Inc Columbia $5.1M $15.0M 85/100
87 The Unumb Center For Neurodevelopment Columbia $5.0M $13.8M
88 Conway Hospital Emergency Professional Services Conway $4.9M $647K 30/100
89 Clemson University Land Stewardship Foundation Inc Clemson $4.9M $74.3M
90 First Tee Greater Charleston Mt Pleasant $4.8M $3.6M 90/100
91 New America Corporation Orangeburg $4.7M $8.0M
92 Delaney Family Foundation Kiawah Island $4.7M $4.6M
93 Jumpstart Spartanburg $4.7M $6.8M
94 Charleston Wine & Food Festival Charleston $4.6M $977K 65/100
95 Growing Home Southeast Inc Cayce $4.5M $3.5M 80/100
96 Peter B & Adeline W Ruffin Foundation Inc Kiawah Island $4.5M $3.0M 75/100
97 Palmetto Academy Of Learning And Success Inc Myrtle Beach $4.4M $1.1M
98 The Wlt Foundation Greenville $4.4M $9.3M
99 Grand Strand Juniors Volleyball Club Surfside Bch $4.4M $1.4M
100 Health Sciences South Carolina Columbia $4.3M $3.8M 85/100

Frequently Asked Questions

What are the largest by revenue nonprofits in South Carolina?

There are 100 nonprofits in South Carolina ranked by largest by revenue, with $2.8B in combined annual revenue.

How are South Carolina nonprofit rankings determined?

Rankings are based on the latest IRS 990 filing data. The biggest nonprofits ranked by total annual revenue. Each organization is ranked relative to other South Carolina nonprofits.

How do South Carolina nonprofits compare nationally?

South Carolina has 100 organizations in this ranking category. View the national largest by revenue rankings for broader context.

Where can I find more nonprofit data for South Carolina?

Visit our South Carolina state page for a complete overview of all nonprofits, or explore specific categories and cities within South Carolina.

Other Rankings for South Carolina

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