Largest by Revenue — Top 100 Nonprofits

The biggest nonprofits ranked by total annual revenue. See which nonprofits score highest and where your donation actually goes. Exposed by IRS 990 tax…

Total Revenue
$13.5B
Average Score
83/100
Highest Revenue
St Lukes Regional Medical Cent
Best Score
Oregon And Southern Idaho Labo
#OrganizationHeadlineStateRevenueScore
1 St Lukes Regional Medical Center ID $5.1B
2 Presbyterian Hospital NC $2.3B
3 Health Research Incorporated Elizabeth Wood Health Research Incorporated Elizabeth Wood operat… NY $1.8B 85/100
4 San Gabriel Pomona Valleys Developmental Services Inc CA $478.6M
5 Truist Foundation Inc FL $290.9M
6 Mercy Hospital Jefferson MO $253.1M
7 Saint Lukes Foundation Of Cleveland Ohio OH $110.9M
8 First Choice Physician Partners TX $110.3M
9 Humangood Pennsylvania CA $107.8M
10 Goodwill Industries Of Upstate Midlands South Carolina Inc SC $97.3M
11 Freestore Foodbank Inc OH $95.1M
12 California Virtual Academies At Los Angeles California Virtual Academies At Los Angeles shows … CA $89.6M 85/100
13 Promedica Coldwater Regional Hospital MI $86.0M
14 Bestself Behavioral Health Inc Bestself Behavioral Health Inc. consistently alloc… NY $84.9M 80/100
15 Grow Early Learning Corp NC $81.0M
16 Goodwill Of Silicon Valley CA $76.4M
17 Buck Institute For Research On Aging CA $73.7M
18 Ohio Valley Goodwill Industries Rehabilitation Center Inc OH $72.9M
19 Kipp Cooper Norcross A New Jersey Nonprofit Corporation NJ $72.4M
20 Continental Divide Electric Cooperative Inc NM $71.2M
21 H R S A I L A Fringe Benefit Fund VA $71.2M
22 National Safety Council IL $70.3M
23 Anthony Wayne Rehabilitation Center For Handicapped & Blind IN $61.5M
24 Shelby Energy Cooperative Inc KY $56.4M
25 Brilla College Preparatory Charter Schools NY $54.2M
26 Bartlett Electric Cooperative Inc TX $47.1M
27 Girl Scouts Of Minnesota And Wisconsin River Valleys Inc MN $45.8M
28 Creation Foundation Inc FL $45.5M
29 Lower Cape Fear Hospice Incorporated NC $45.1M
30 Heading Home Inc MA $43.0M
31 Carolina Medicorp Enterprises Llc NC $42.1M
32 Northwest Energy Efficiency Alliance Inc OR $41.1M
33 Jacob & Terese Hershey Foundation TX $39.7M
34 Columbus Center For Human Services Inc OH $39.1M
35 Avon Grove Charter School PA $38.4M
36 Life Patterns Inc KS $35.6M
37 Edward Waters University Inc FL $35.2M
38 United Electric Cooperative Inc PA $35.1M
39 South Coast Childrens Society Inc CA $34.3M
40 Webb School TN $34.3M
41 A Second Chance Inc PA $32.4M
42 Area Agency On Aging For Southwest Florida Inc FL $32.0M
43 Kean University Foundation Inc Kean University Foundation: Strong Asset Growth, M… NJ $31.8M 75/100
44 Portsmouth Hospital Corporation OH $30.2M
45 Midland Christian School TX $29.3M
46 Boys & Girls Clubs Of Metropolitan Baltimore MD $29.2M
47 Lasell Village Inc Lasell Village: Strong Mission, High Liabilities, … MA $29.0M 85/100
48 Eagle Community Credit Union CA $28.1M
49 International Union Of Operating Engineers 68 68 A 68 B International Union Of Operating Engineers 68 68 A… NJ $27.6M 85/100
50 Belle Meade Country Club TN $27.1M
51 Reach Out And Read Inc MA $26.8M
52 Boy Scouts Of America PA $25.8M
53 Kentucky River Area Development District Inc KY $25.7M
54 Summit School Summit School shows consistent revenue growth and … NY $25.4M 88/100
55 Valencia College Foundation FL $25.4M
56 Childrens Diagnostic & Treatment Center Inc FL $25.1M
57 Maine Coast Heritage Trust ME $23.3M
58 Phipps Conservatory And Botanical Gardens Inc PA $22.3M
59 Indian Land Tenure Foundation MN $21.9M
60 Mercy Ships Foundation TX $21.9M
61 Health Care Partners Of South Carolina Inc SC $21.8M
62 International Tennis Hall Of Fame Incorporated International Tennis Hall Of Fame shows strong fin… RI $21.3M 90/100
63 Indian River State College Fdn Inc FL $20.5M
64 3 M Employees Benefit Association MN $20.2M
65 Penn Club Of New York Inc NY $19.8M
66 Delaware County Christian School Society PA $19.7M
67 Florentine Opera Co Inc WI $19.3M
68 Boca Wood Country Club Association Inc FL $19.2M
69 Association Of American Publishers Inc Association Of American Publishers Inc shows volat… DC $18.9M 65/100
70 Center For Specialized Realtor Education Inc IL $18.7M
71 Iowa Hospital Association IA $18.5M
72 Schofield Residence Inc Schofield Residence Inc. maintains stable operatio… NY $18.2M 80/100
73 Ten Thousand Villages PA $17.6M
74 Willard L Eccles Charitable Foundation UT $17.5M
75 Starvista CA $17.5M
76 Joanne W Guantt Charitable Foundation IL $17.1M
77 Learning With A Difference Inc CA $17.0M
78 Community Health Center Of Buffalo Inc Community Health Center Of Buffalo Inc maintains s… NY $16.9M 92/100
79 Childrens Surgical Associates Of Nj Inc PA $16.8M
80 American Hockey League American Hockey League consistently operates at br… MA $16.2M 75/100
81 Pilgrim Foundation DE $16.0M
82 The Brunson Foundation CA $15.8M
83 Equality Community Housing Corporation AZ $15.7M
84 Southern Oregon University Foundation OR $15.3M
85 Chicago Education Partnership IL $14.8M
86 Westminster Presbyterian Center Inc SC $14.5M
87 Project Genesis Incorporated CT $14.2M
88 Defense Energy Center Of Excellence OR $14.1M
89 Set Free Alaska AK $14.1M
90 High International Home Furnishings Market Authority Corp NC $13.9M
91 Addenbrooke Classical Academy Inc CO $13.4M
92 First Midwest Charitable Foundation IL $12.6M
93 Rochester Area Foundation MN $12.6M
94 Winthrop University Foundation SC $12.5M
95 Community Foundation Of Northwest Mississippi Inc MS $12.4M
96 United Way Of Northern New Jersey Inc United Way Of Northern New Jersey: Strong Asset Gr… NJ $12.1M 75/100
97 American Bankruptcy Institute VA $11.1M
98 Oregon And Southern Idaho Laborers Employers Training Tr Oregon And Southern Idaho Laborers Employers Train… OR $11.1M 95/100
99 Educators For Excellence NY $11.0M
100 Cole County Lutheran Home Assoc MO $10.9M

Key Insights

Frequently Asked Questions

What are the top nonprofits by largest by revenue?

The top nonprofits ranked by largest by revenue include St Lukes Regional Medical Center, Presbyterian Hospital, Health Research Incorporated Elizabeth Wood and more. These organizations are ranked based on revenue, transparency, and AI-analyzed mission alignment scores.

How are nonprofits ranked?

Nonprofits are ranked using a combination of financial data from IRS Form 990 filings, AI-powered mission alignment analysis, and transparency metrics. Revenue size, governance practices, and program effectiveness all factor into the final ranking.

What does the Mission Score mean?

The Mission Score is an AI-generated rating from 0 to 100 that evaluates how effectively a nonprofit aligns its spending and programs with its stated mission. Higher scores indicate stronger alignment between stated goals and actual financial activity.

How often are rankings updated?

Rankings are updated quarterly as new IRS Form 990 filings become available. AI enrichment and scoring are re-run with each data refresh to ensure the most current analysis is reflected.

How can I use these rankings?

These rankings help donors, researchers, and journalists identify high-performing nonprofits by largest by revenue. Use them to compare organizations, verify financial transparency, and make informed giving decisions based on data rather than marketing.

About Nonprofit Rankings

NonprofitSpending rankings are built on a rigorous methodology combining public IRS Form 990 data with AI-powered analysis. Each organization is evaluated across multiple dimensions including financial health, program spending ratios, executive compensation reasonableness, governance transparency, and mission alignment.

Our AI enrichment pipeline analyzes each filing to generate honest headlines, risk assessments, and mission scores. Unlike simple revenue rankings, our approach rewards organizations that demonstrate efficient use of funds, clear governance structures, and measurable impact toward their stated charitable purpose.

Data is sourced from the IRS Exempt Organizations Business Master File and electronically filed Form 990 returns. All analysis is automated and objective — no nonprofit can pay for a higher ranking or score.

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